Details

Autor(en) / Beteiligte

• Coll, Francesc
• Harrison, Ewan M
• Toleman, Michelle S
• Reuter, Sandra
• Raven, Kathy E
• Blane, Beth
• Palmer, Beverley
• Kappeler, A Ruth M
• Brown, Nicholas M
• Török, M Estée
• Parkhill, Julian
• Peacock, Sharon J

Titel

Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community

Ist Teil von

• Science translational medicine, 2017-10, Vol.9 (413)

Ort / Verlag

United States

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Genome sequencing has provided snapshots of the transmission of methicillin-resistant (MRSA) during suspected outbreaks in isolated hospital wards. Scale-up to populations is now required to establish the full potential of this technology for surveillance. We prospectively identified all individuals over a 12-month period who had at least one MRSA-positive sample processed by a routine diagnostic microbiology laboratory in the East of England, which received samples from three hospitals and 75 general practitioner (GP) practices. We sequenced at least 1 MRSA isolate from 1465 individuals (2282 MRSA isolates) and recorded epidemiological data. An integrated epidemiological and phylogenetic analysis revealed 173 transmission clusters containing between 2 and 44 cases and involving 598 people (40.8%). Of these, 118 clusters (371 people) involved hospital contacts alone, 27 clusters (72 people) involved community contacts alone, and 28 clusters (157 people) had both types of contact. Community- and hospital-associated MRSA lineages were equally capable of transmission in the community, with instances of spread in households, long-term care facilities, and GP practices. Our study provides a comprehensive picture of MRSA transmission in a sampled population of 1465 people and suggests the need to review existing infection control policy and practice.