Details

Autor(en) / Beteiligte

• Kikkawa, U
• Ogita, K
• Shearman, M S
• Ase, K
• Sekiguchi, K
• Naor, Z
• Ido, M
• Nishizuka, Y
• Saito, N
• Tanaka, C

Titel

The heterogeneity and differential expression of protein kinase C in nervous tissues

Ist Teil von

• Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1988-07, Vol.320 (1199), p.313-324

Ort / Verlag

England

Erscheinungsjahr

1988

Quelle

MEDLINE

Beschreibungen/Notizen

• Protein kinase C exists as a large family of multiple subspecies with subtle individual characteristics. This heterogeneity comes from different genes as well as from different splicings of a single RNA transcript. The members of this family have closely related structures with a high degree of homology. Biochemical studies have shown that their mode of activation and kinetic and catalytic properties differ slightly from one another. By using a combination of biochemical and immunocytochemical techniques, their differential regional and cellular expression have been shown in the nervous tissues. Each member of this enzyme family may have a specialized function in transducing various physiological and pathological signals into different cell types.