Details

Autor(en) / Beteiligte

• Tzeng, Nian-Sheng
• Chung, Chi-Hsiang
• Lin, Fu-Huang
• Huang, Ching-Feng
• Yeh, Chin-Bin
• Huang, San-Yuan
• Lu, Ru-Band
• Chang, Hsin-An
• Kao, Yu-Chen
• Yeh, Hui-Wen
• Chiang, Wei-Shan
• Chou, Yu-Ching
• Tsao, Chang-Huei
• Wu, Yung-Fu
• Chien, Wu-Chien

Titel

Magnesium oxide use and reduced risk of dementia: a retrospective, nationwide cohort study in Taiwan

Ist Teil von

• Current medical research and opinion, 2018-01, Vol.34 (1), p.163-169

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: Dietary magnesium may be associated with a lower risk of dementia; however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia. Methods: We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged ≥50 years with no history of MgO usage. A total of 1547 patients who had used MgO were enrolled, along with 4641 controls who had not used the MgO propensity score matched by age, gender and comorbidity, at a ratio of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing dementia during a 10 year follow-up period. Results: Of the enrolled patients, 44 (2.84%) developed dementia, when compared to 199 (4.28%) in the control group. The Cox proportional hazards regression analysis revealed that the patients who had used MgO were less likely to develop dementia with a crude hazard ratio of 0.617 (95% CI, 0.445-0.856, p = .004). After adjusting for age, gender, comorbidity, geographical area and urbanization level of residence, and monthly income, the adjusted hazard ratio was 0.517 (95% CI, 0.412-0.793, p = .001). Conclusions: The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted.