Details

Autor(en) / Beteiligte

• Jäger, Wolfgang
• Moskalev, Igor
• Raven, Peter
• Goriki, Akihiro
• Bidnur, Samir
• Black, Peter C

Titel

Orthotopic Mouse Models of Urothelial Cancer

Ist Teil von

• Methods in molecular biology (Clifton, N.J.), 2018, Vol.1655, p.177

Ort / Verlag

United States

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Orthotopic mouse models of urothelial cancer are essential for testing novel therapies and molecular manipulations of cell lines in vivo. These models are either established by orthotopic inoculation of human (xenograft models) or murine tumor cells (syngeneic models) in immunocompromised or immune competent mice. Current techniques rely on inoculation by intravesical instillation or direct injection into the bladder wall. Alternative models include the induction of murine bladder tumors by chemical carcinogens (BBN) or genetic engineering (GEM).