Inhibitory effect of ilexpernoside C from Ilex pernyi on aggregated LDL-induced foam cells formation
2016
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- Autor(en) / Beteiligte
- Titel
- Inhibitory effect of ilexpernoside C from Ilex pernyi on aggregated LDL-induced foam cells formation
- Ist Teil von
- Zhongguo zhongyao zazhi, 2016-02, Vol.41 (3), p.498
- Ort / Verlag
- China
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The aggregation of macrophage-derived foam cells on vascular wall is considered to be a main cause of atherosclerosis. In the present study, we evaluated the inhibitory effect of the compound ilexpernoside C (IC1) extracted from Ilex pernyi (Aquifoliaceae) on foam cell formation in THP-1 macrophages cells which were induced by low density lipoproteins aggregates (LDL aggregates). Results showed that IC1 could significantly inhibit the formation of foam cells. The analysis on related receptors of foam cells indicated that IC1 could significantly decrease the expression of low density lipoprotein-related receptor 1(LRP1). Therefore, these findings indicated that IC1 inhibited the formation of foam cells by inhibiting endocytosis of macrophages, thus it may act as a potential anti-atherosclerotic agent.
- Sprache
- Chinesisch; Englisch
- Identifikatoren
- ISSN: 1001-5302DOI: 10.4268/cjcmm20160323Titel-ID: cdi_pubmed_primary_28868870
- Format
- –
- Schlagworte
- Drugs, Chinese Herbal - pharmacology, Foam Cells - cytology, Foam Cells - drug effects, Humans, Ilex - chemistry, Lipoproteins, LDL - metabolism, Low Density Lipoprotein Receptor-Related Protein-1 - genetics, Low Density Lipoprotein Receptor-Related Protein-1 - metabolism, Macrophages - cytology, Macrophages - drug effects