Details

Autor(en) / Beteiligte

• Rijk, Yvonne
• van Alfen-van der Velden, Janielle
• Claahsen-van der Grinten, Hedi L

Titel

Prenatal Treatment with Dexamethasone in Suspected Congenital Adrenal Hyperplasia and Orofacial Cleft: a Case Report and Review of the Literature

Ist Teil von

• Pediatric endocrinology reviews : PER, 2017-09, Vol.15 (1), p.21

Ort / Verlag

Israel

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Congenital adrenal hyperplasia (CAH) due to 21 hydroxylase deficiency is a genetic disorder that leads to hypocortisolism, hyperandrogenism and, in the most severe forms, also to hypoaldosteronism. Girls with classic CAH are born with virilized external genitalia. Prenatal dexamethasone (DXM) treatment can reduce virilization but may have side effects for mother and fetus. We present the first case of a girl who was born with CAH and an orofacial cleft. She was treated with prenatal DXM to prevent virilization. Oral clefts have to be considered as a potential side effect of prenatal DXM treatment.