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Th1-Inducing Agents in Prophylaxis and Therapy for Paracoccidioidomycosis
Ist Teil von
Methods in molecular biology (Clifton, N.J.), 2017, Vol.1625, p.159
Ort / Verlag
United States
Erscheinungsjahr
2017
Link zum Volltext
Beschreibungen/Notizen
Adjuvants and immunomodulatory molecules could be included in the treatment of P. brasiliensis infection. In this context, we reported that the therapeutic and/or prophylactic administration of Th1-inducing agents, such as immunomodulatory lectins and adjuvants, was able to provide protection against experimental paracoccidioidomycosis. Then, we described the protocols to investigate the effect of immunomodulatory agents on the course of P. brasiliensis infection. In this sense, we detailed the measurement of fungal burden and cytokine production, and the histopathological analysis used to evaluate the most effective administration regime.