Neurochemical research, 2017-09, Vol.42 (9), p.2639
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Senicapoc: Repurposing a Drug to Target Microglia K Ca 3.1 in Stroke
- Ist Teil von
- Neurochemical research, 2017-09, Vol.42 (9), p.2639
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Stroke is the leading cause of serious long-term disability and the fifth leading cause of death in the United States. Treatment options for stroke are few in number and limited in efficacy. Neuroinflammation mediated by microglia and infiltrating peripheral immune cells is a major component of stroke pathophysiology. Interfering with the inflammation cascade after stroke holds the promise to modulate stroke outcome. The calcium activated potassium channel K 3.1 is expressed selectively in the injured CNS by microglia. K 3.1 function has been implicated in pro-inflammatory activation of microglia and there is recent literature suggesting that this channel is important in the pathophysiology of ischemia/reperfusion (stroke) related brain injury. Here we describe the potential of repurposing Senicapoc, a K 3.1 inhibitor, to intervene in the inflammation cascade that follows ischemia/reperfusion.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1573-6903Titel-ID: cdi_pubmed_primary_28364331
- Format
- –
- Schlagworte
- Acetamides - administration & dosage, Animals, Drug Delivery Systems - methods, Drug Repositioning - methods, Humans, Intermediate-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors, Intermediate-Conductance Calcium-Activated Potassium Channels - metabolism, Microglia - drug effects, Microglia - metabolism, Pyrazoles - administration & dosage, Stroke - drug therapy, Stroke - metabolism, Trityl Compounds - administration & dosage