Details

Autor(en) / Beteiligte

• Koelsch, Kersten K
• Rasmussen, Thomas A
• Hey-Nguyen, William J
• Pearson, Chester
• Xu, Yin
• Bailey, Michelle
• Marks, Katherine H
• Sasson, Sarah C
• Taylor, Mark S
• Tantau, Robyn
• Obeid, Solange
• Milner, Brad
• Morrissey, Orla
• Pinto, Angie N
• Suzuki, Kazuo
• Busch, Michael P
• Keating, Sheila M
• Kaiser, Philipp
• Yukl, Steven
• Wong, Joseph K
• Hiener, Bonnie M
• Palmer, Sarah
• Zaunders, John
• Post, Jeffrey J
• Chan, Derek J
• Avery, Sharon
• Milliken, Sam T
• Kelleher, Anthony D
• Lewin, Sharon R
• Cooper, David A

Titel

Impact of Allogeneic Hematopoietic Stem Cell Transplantation on the HIV Reservoir and Immune Response in 3 HIV-Infected Individuals

Ist Teil von

• Journal of acquired immune deficiency syndromes (1999), 2017-07, Vol.75 (3), p.328-337

Ort / Verlag

United States

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Allogeneic hematopoietic stem cell transplantation (HSCT) can lead to significant changes to the HIV reservoir and HIV immune responses, indicating that further characterization of HIV-infected patients undergoing HSCT is warranted. We studied 3 patients who underwent HSCT after either reduced intensity conditioning or myeloablative conditioning regimen. We measured HIV antigens and antibodies (Ag/Ab), HIV-specific CD4 T-cell responses, HIV RNA, and DNA in plasma, peripheral blood mononuclear cells, isolated CD4 T cells from peripheral blood, and lymph node cells. The patients remained on antiretroviral therapy throughout the follow-up period. All patients have been in continued remission for 4-6 years post-HSCT. Analyses of HIV RNA and DNA levels showed substantial reductions in HIV reservoir-related measurements in all 3 patients, changes in immune response varied with pronounced reductions in 2 patients and a less dramatic reduction in 1 patient. One patient experienced unexpected viral rebound 4 years after HSCT. These 3 cases highlight the substantial changes to the HIV reservoir and the HIV immune response in patients undergoing allogeneic HSCT. The viral rebound observed in 1 patient indicates that replication competent HIV can re-emerge several years after HSCT despite these marked changes.