Details

Autor(en) / Beteiligte

• Li, Changwei
• Kim, Yun Kyoung
• Dorajoo, Rajkumar
• Li, Huaixing
• Lee, I-Te
• Cheng, Ching-Yu
• He, Meian
• Sheu, Wayne H-H
• Guo, Xiuqing
• Ganesh, Santhi K
• He, Jiang
• Lee, Juyoung
• Liu, Jianjun
• Hu, Yao
• Rao, Dabeeru C
• Tsai, Fuu-Jen
• Koh, Jia Yu
• Hu, Hua
• Liang, Kae-Woei
• Palmas, Walter
• Hixson, James E
• Han, Sohee
• Teo, Yik-Ying
• Wang, Yiqin
• Chen, Jing
• Lu, Chieh Hsiang
• Zheng, Yingfeng
• Gui, Lixuan
• Lee, Wen-Jane
• Yao, Jie
• Gu, Dongfeng
• Han, Bok-Ghee
• Sim, Xueling
• Sun, Liang
• Zhao, Jinying
• Chen, Chien-Hsiun
• Kumari, Neelam
• He, Yunfeng
• Taylor, Kent D
• Raffel, Leslie J
• Moon, Sanghoon
• Rotter, Jerome I
• Ida Chen, Yii-der
• Wu, Tangchun
• Wong, Tien Yin
• Wu, Jer-Yuarn
• Lin, Xu
• Tai, E-Shyong
• Kim, Bong-Jo
• Kelly, Tanika N

Titel

Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians

Ist Teil von

• Circulation. Cardiovascular genetics, 2017-04, Vol.10 (2), p.e001527

Ort / Verlag

United States

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP. We conducted genome-wide analysis among 18 422 East Asian participants (stage 1) followed by replication study of ≤46 629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a <5.0×10 and 2.5×10 , respectively, in joint analyses of stage-1 and stage-2 data. We identified 1 novel variant, rs4919669 at 10q24.32, influencing LTA systolic BP (stage-1 =5.03×10 , stage-2 =8.64×10 , joint =2.63×10 ) and mean arterial pressure (stage-1 =3.59×10 , stage-2 =2.35×10 , joint =2.64×10 ). Three previously reported BP loci ( , , and ) were also identified for all BP phenotypes. Gene-based analysis provided the first robust evidence for association of with LTA systolic BP (stage-1 =8.55×10 , stage-2 =1.62×10 , joint =3.28×10 ) and mean arterial pressure (stage-1 =9.19×10 , stage-2 =9.69×10 , joint =2.15×10 ) phenotypes. Fourteen genes ( , , , , , , , , - , , , and at 10q24.32; at 12q21.33; and at 11p15.1) implicated by previous genome-wide association study meta-analyses were also identified. Among the loci identified by the previous genome-wide association study meta-analysis of LTA BP, we transethnically replicated associations of the marker rs1275988 at 2p23.3 with LTA systolic BP and mean arterial pressure phenotypes ( =1.27×10 and 3.30×10 , respectively). We identified 1 novel variant and 1 novel gene and present the first direct evidence of relevance of the locus for LTA BP among East Asians.