Details

Autor(en) / Beteiligte

• Weikum, Emily R
• Knuesel, Matthew T
• Ortlund, Eric A
• Yamamoto, Keith R

Titel

Glucocorticoid receptor control of transcription: precision and plasticity via allostery

Ist Teil von

• Nature reviews. Molecular cell biology, 2017-03, Vol.18 (3), p.159

Ort / Verlag

England

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. The precision of GR-mediated responses seems to depend on combinatorial, context-specific assembly of GR-nucleated transcription regulatory complexes at genomic response elements. In turn, evidence suggests that context-driven plasticity is conferred by the integration of multiple signals, each serving as an allosteric effector of GR conformation, a key determinant of regulatory complex composition and activity. This structural and mechanistic perspective on GR regulatory specificity is likely to extend to other eukaryotic TRFs.