Heart (British Cardiac Society), 2017-04, Vol.103 (8), p.599
2017
Details
- Autor(en) / Beteiligte
- Titel
- Haemodynamic effects of riociguat in inoperable/recurrent chronic thromboembolic pulmonary hypertension
- Ist Teil von
- Heart (British Cardiac Society), 2017-04, Vol.103 (8), p.599
- Ort / Verlag
- England
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We compared the haemodynamic effects of riociguat in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or persistent/recurrent CTEPH after pulmonary endarterectomy in the Chronic Thromboembolic Pulmonary Hypertension Soluble Guanylate Cyclase-Stimulator Trial 1 study. Patients with inoperable or persistent/recurrent CTEPH (n=261; mean± SD age 59±14 years; 66% women) were randomised to riociguat (up to 2.5 mg three times daily) or placebo. Haemodynamic parameters were assessed at baseline and week 16. Riociguat decreased pulmonary vascular resistance (PVR) in inoperable (n=189; least-squares mean difference: -285 dyn s/cm (95% CI -357 to -213); p<0.0001) and persistent/recurrent (n=72; -131 dyn s/cm (95% CI -214 to -48); p=0.0025) patients. Cardiac index improved in inoperable patients by a least-squares mean difference of +0.6 L/min/m (95% CI 0.4 to 0.7; p<0.0001), while in persistent/recurrent patients the change was +0.2 L/min/m (95% CI -0.1 to 0.5; p=0.17). Mean pulmonary artery pressure decreased in inoperable and persistent/recurrent patients(-4.7 mm Hg (95% CI -6.9 to -2.6; p<0.0001 and -4.8 mm Hg (-8.2 to -1.5; p=0.0055), respectively). For all patients, changes in 6 min walk distance correlated with changes in PVR (r=-0.29 (95% CI -0.41 to -0.17); p<0.0001) and cardiac index (r=0.23 (95% CI 0.10 to 0.35); p=0.0004). Riociguat improved haemodynamics in patients with inoperable CTEPH or persistent/recurrent CTEPH. NCT00855465.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1468-201XDOI: 10.1136/heartjnl-2016-309621Titel-ID: cdi_pubmed_primary_28011757
- Format
- –
- Schlagworte
- Aged, Antihypertensive Agents - adverse effects, Antihypertensive Agents - therapeutic use, Arterial Pressure - drug effects, Chronic Disease, Double-Blind Method, Endarterectomy, Exercise Tolerance - drug effects, Female, Humans, Hypertension, Pulmonary - diagnosis, Hypertension, Pulmonary - drug therapy, Hypertension, Pulmonary - etiology, Hypertension, Pulmonary - physiopathology, Least-Squares Analysis, Male, Middle Aged, Prospective Studies, Pulmonary Artery - drug effects, Pulmonary Artery - physiopathology, Pulmonary Embolism - complications, Pulmonary Embolism - diagnosis, Pyrazoles - adverse effects, Pyrazoles - therapeutic use, Pyrimidines - adverse effects, Pyrimidines - therapeutic use, Recovery of Function, Recurrence, Time Factors, Treatment Outcome, Vascular Resistance - drug effects, Walk Test