Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016-12, Vol.36 (12), p.1667
2016
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- Autor(en) / Beteiligte
- Titel
- Expression of mir-106b in esophageal squamous cell carcinoma
- Ist Teil von
- Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016-12, Vol.36 (12), p.1667
- Ort / Verlag
- China
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the expression of mir-106b in esophageal squamous cell carcinoma (ESCC) tissue and analyze its correlation with the clinicopathologic features of ESCC. A total of 200 fresh surgical specimens of ESCC and adjacent tissues collected between 2001 and 2007 were examined for expressions of mir-106b using real-time PCR (RT-PCR). Northern blot analysis for mir-106b was performed in 4 pairs of samples to confirm the RT-PCR results. The relationship between mir-106b expression and clinicopathological features and prognosis of the patients were analyzed. Mir-106b was expressed at significantly higher levels in ESCC tissues than in the paired adjacent tissues. Overexpression of mir-106b was associated with lymph node metastasis, stage of TNM classification and smoking (P<0.05). The survival rate of patients with low mir-106b expression was higher than that of patients with high mir-106b expression (60 vs 37 months, P=0.024). Cox regression analysis indicated that the expression of mir-106b, lymph node met
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1673-4254Titel-ID: cdi_pubmed_primary_27998862
- Format
- –
- Schlagworte
- Biomarkers, Tumor, Carcinoma, Squamous Cell - metabolism, Esophageal Neoplasms - metabolism, Esophageal Squamous Cell Carcinoma, Gene Expression Regulation, Neoplastic, Humans, Lymphatic Metastasis, MicroRNAs - metabolism, Neoplasm Staging, Prognosis, Real-Time Polymerase Chain Reaction, Survival Rate