Details

Autor(en) / Beteiligte

• Marchler-Bauer, Aron
• Bo, Yu
• Han, Lianyi
• He, Jane
• Lanczycki, Christopher J
• Lu, Shennan
• Chitsaz, Farideh
• Derbyshire, Myra K
• Geer, Renata C
• Gonzales, Noreen R
• Gwadz, Marc
• Hurwitz, David I
• Lu, Fu
• Marchler, Gabriele H
• Song, James S
• Thanki, Narmada
• Wang, Zhouxi
• Yamashita, Roxanne A
• Zhang, Dachuan
• Zheng, Chanjuan
• Geer, Lewis Y
• Bryant, Stephen H

Titel

CDD/SPARCLE: functional classification of proteins via subfamily domain architectures

Ist Teil von

• Nucleic acids research, 2017-01, Vol.45 (D1), p.D200

Ort / Verlag

England

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionarily conserved protein domain footprints, and functional sites inferred from such footprints. An archive of pre-computed domain annotation is maintained for proteins tracked by NCBI's Entrez database, and live search services are offered as well. CDD curation staff supplements a comprehensive collection of protein domain and protein family models, which have been imported from external providers, with representations of selected domain families that are curated in-house and organized into hierarchical classifications of functionally distinct families and sub-families. CDD also supports comparative analyses of protein families via conserved domain architectures, and a recent curation effort focuses on providing functional characterizations of distinct subfamily architectures using SPARCLE: Subfamily Protein Architecture Labeling Engine. CDD can be accessed at https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.