Details

Autor(en) / Beteiligte

• Zhang, Na
• Feng, Ze-Guo
• Wang, Ru-Huan
• Zhang, Wei-Dong
• Yu, Jun
• DU, Chun-Yan
• Wang, Hai

Titel

Synergistic analgesic effect of choline and parecoxib sodium in mice and the mechanism

Ist Teil von

• Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016-11, Vol.36 (11), p.1536

Ort / Verlag

China

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the synergistic analgesic effect of choline and parecoxib sodium and study its mechanism. In male Kunming mice with acetic acid-induced writhing, the ED of choline and parecoxib sodium (administered via the tail vein at 2 h and 30 min before modeling, respectively) and their combined use were determined. In saline (control) group, ED choline (C) group, ED parecoxib sodium (P) group, and 1/2ED choline and parecoxib sodium (1/2[C+P]) group, blood samples were collected from the eyeball 10 min after intraperitoneal administration of acetic acid to detect the levels of IL-1, TNF-α, PGE2, NF-κB, and I-κB levels using ELISA kits. In the acetic acid-induced writhing model, the ED of choline and parecoxib sodium was 8.64 and 6.33 mg/kg, and when combined, their ED50 was 2.13 and 1.56 mg/kg, respectively. The isobolograms of parecoxib sodium and choline showed that the measured ED of the two drugs combined was below the theoretical ED value (P<0.05) with a combination index (CI) of <0.9. Compared with t