Details

Autor(en) / Beteiligte

• Ong, Sang-Bing
• Hausenloy, Derek J.
• Singh, Harpreet
• Sheu, Shey-Shing

Titel

Mitochondrial Dynamics as a Therapeutic Target for Treating Cardiac Diseases

Ist Teil von

• Handbook of experimental pharmacology, 2017, Vol.240, p.251-279

Ort / Verlag

Switzerland: Springer International Publishing AG

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Mitochondria are dynamic in nature and are able to shift their morphology between elongated interconnected mitochondrial networks and a fragmented disconnected arrangement by the processes of mitochondrial fusion and fission, respectively. Changes in mitochondrial morphology are regulated by the mitochondrial fusion proteins – mitofusins 1 and 2 (Mfn1 and 2), and optic atrophy 1 (Opa1) as well as the mitochondrial fission proteins – dynamin-related peptide 1 (Drp1) and fission protein 1 (Fis1). Despite having a unique spatial arrangement, cardiac mitochondria have been implicated in a variety of disorders including ischemia–reperfusion injury (IRI), heart failure, diabetes, and pulmonary hypertension. In this chapter, we review the influence of mitochondrial dynamics in these cardiac disorders as well as their potential as therapeutic targets in tackling cardiovascular disease.