Advances in experimental medicine and biology, 2016, Vol.924, p.187-189
2016
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Detection and Quantification of KIT Mutations in ctDNA by Plasma Safe-SeqS
- Ist Teil von
- Advances in experimental medicine and biology, 2016, Vol.924, p.187-189
- Ort / Verlag
- Cham: Springer International Publishing
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We have designed a highly sensitive assay based on the Safe-SeqS technology to detect de novo mutations in the KIT gene and tested its performance. This assay was applied to plasma samples of GIST patients before and after treatment with a multikinase inhibitor and mutations at known and novel sites of potential secondary resistance were identified.
- Sprache
- Englisch
- Identifikatoren
- ISBN: 3319420429, 9783319420424ISSN: 0065-2598eISSN: 2214-8019DOI: 10.1007/978-3-319-42044-8_34Titel-ID: cdi_pubmed_primary_27753042
- Format
- –
- Schlagworte
- Antineoplastic Agents - therapeutic use, ctDNA, DNA Mutational Analysis - methods, Gastrointestinal Neoplasms - blood, Gastrointestinal Neoplasms - drug therapy, Gastrointestinal Neoplasms - genetics, Gastrointestinal Stromal Tumors - blood, Gastrointestinal Stromal Tumors - drug therapy, Gastrointestinal Stromal Tumors - genetics, GIST, Humans, Imatinib Mesylate - therapeutic use, Indoles - therapeutic use, Mutation, NGS, Outcome Assessment (Health Care) - methods, Phenylurea Compounds - therapeutic use, Proto-Oncogene Proteins c-kit - genetics, Pyridines - therapeutic use, Pyrroles - therapeutic use, Reproducibility of Results, Safe-SeqS, Secondary resistance