Details

Autor(en) / Beteiligte

• MORI, Koji
• KAIDO, Masanobu
• FUJISHIRO, Kazuya
• INOUE, Naohide
• HORI, Hajime

Titel

Effects of Inhalation of Ethylene Oxide on Female Rats

Ist Teil von

• Journal of UOEH, 1989/06/01, Vol.11(2), pp.173-179

Ort / Verlag

Japan: The University of Occupational and Environmental Health, Japan

Erscheinungsjahr

1989

Quelle

MEDLINE

Beschreibungen/Notizen

• The effects of systemic toxicity including reproductive toxicity of ethylene oxide on female rats were studied. When Wistar female rats were exposed to 250 ppm of ethylene oxide for six hours a day, five days a week for ten weeks, they showed inhibition of body weight gain and paralysis of the hindlegs. Hematological examination revealed macrocytic and normochronic anemia with high reticulocyte counts. The estrus cycle of the exposed group was prolonged and the percentage of the diestrus stage increased. There was no atrophy in the ovary or the uterus. However, the activity of glutathione reductase in the ovary decreased by 18% and that of glutathione －S－ transferase increased by 30%. These results indicate that ethylene oxide has a similar effect on both female and male rats and that the female reproductive system is also affected.