Details

Autor(en) / Beteiligte

• Martel, Clothilde
• Vignaud, Guillaume
• Liozon, Eric
• Magy, Laurent
• Gallouedec, Gael
• Ly, Kim
• Bezanahary, Holly
• Cypierre, Anne
• Lapébie, François-Xavier
• Palat, Sylvain
• Gondran, Guillaume
• Jauberteau, Marie-Odile
• Fauchais, Anne-Laure

Titel

Contribution of dot-blot assay to the diagnosis and management of myositis: a three-year practice at a university hospital centre

Ist Teil von

• Clinical and experimental rheumatology, 2016-09, Vol.34 (5), p.918

Ort / Verlag

Italy

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Idiopathic inflammatory myopathies (IIM) are heterogeneous autoimmune diseases with wide clinical spectrum that may lead to delayed diagnosis. The aim of this study was to examine the impact of IIM-specific dot-blot assay on diagnostic process of patients presenting with muscular or systemic symptoms evocating of IIM. We collected all the prescriptions of an IIM specific dot-blot assay (8 autoantigens including Jo-1, PL-7, PL-12, SRP, Mi-2, Ku, PM/Scl and Scl-70) over a 38-month period. 316 myositis dot-blot assays (MSD) were performed in 274 patients (156 women, mean age 53±10.6 years) referring for muscular and/or systemic symptoms suggesting IIM. The timing of dot prescription through the diagnostic process was highly variable: without (35%), concomitantly (16%) or after electromyographic studies (35%). Fifty-nine patients (22%) had IIM according to Bohan and Peter's criteria. Among them, 29 (49%) had positive dot (8 Jo-1, 6 PM-Scl, 5 PL-12, 5 SRP, 2 Mi-2, 2 PL-7 and 1 Ku). Various other diagnoses were performed including 35 autoimmune disease or granulomatosis (12%), 19 inflammatory rheumatic disease (7%), 16 non inflammatory muscular disorders (6%), 10 drug-induced myalgia (4%), 11 infectious myositis (4%). Except 11 borderline SRP results and one transient PM-Scl, MSD was positive only in one case of IIM. Dot allowed clinicians to correct diagnosis in 4 cases and improved the diagnosis of IIM subtypes in 4 cases. This study reflects the interest of myositis dot in the rapid diagnosis process of patients with non-specific muscular symptoms leading to various diagnoses including IIM.