Details

Autor(en) / Beteiligte

• Shemesh, Yair
• Forkosh, Oren
• Mahn, Mathias
• Anpilov, Sergey
• Sztainberg, Yehezkel
• Manashirov, Sharon
• Shlapobersky, Tamar
• Elliott, Evan
• Tabouy, Laure
• Ezra, Gili
• Adler, Elaine S
• Ben-Efraim, Yair J
• Gil, Shosh
• Kuperman, Yael
• Haramati, Sharon
• Dine, Julien
• Eder, Matthias
• Deussing, Jan M
• Schneidman, Elad
• Yizhar, Ofer
• Chen, Alon

Titel

Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics

Ist Teil von

• Nature neuroscience, 2016-11, Vol.19 (11), p.1489-1496

Ort / Verlag

United States

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Social encounters are associated with varying degrees of emotional arousal and stress. The mechanisms underlying adequate socioemotional balance are unknown. The medial amygdala (MeA) is a brain region associated with social behavior in mice. Corticotropin-releasing factor receptor type-2 (CRF-R2) and its specific ligand urocortin-3 (Ucn3), known components of the behavioral stress response system, are highly expressed in the MeA. Here we show that mice deficient in CRF-R2 or Ucn3 exhibit abnormally low preference for novel conspecifics. MeA-specific knockdown of Crfr2 (Crhr2) in adulthood recapitulated this phenotype. In contrast, pharmacological activation of MeA CRF-R2 or optogenetic activation of MeA Ucn3 neurons increased preference for novel mice. Furthermore, chemogenetic inhibition of MeA Ucn3 neurons elicited pro-social behavior in freely behaving groups of mice without affecting their hierarchal structure. These findings collectively suggest that the MeA Ucn3-CRF-R2 system modulates the ability of mice to cope with social challenges.