Details

Autor(en) / Beteiligte

• Porretta, G C
• Cerreto, F
• Fioravanti, R
• Biava, M
• Scalzo, M
• Simonetti, N
• D'Auria, F D

Titel

Substances with antibacterial and antifungal activity. VII. Synthesis and microbiologic activity of new derivatives of 1,5-diarylpyrrole

Ist Teil von

• Farmaco (Società chimica italiana : 1989), 1989-01, Vol.44 (1), p.65

Ort / Verlag

France

Erscheinungsjahr

1989

Quelle

MEDLINE

Beschreibungen/Notizen

• The synthesis and antifungal activities of new 1,5-diarylpyrrole derivatives are reported. Antimicrobial data in comparison with pyrrolnitrin show that N-methylpiperazinylamides exhibit very poor activity against Candida albicans and Candida sp. while acid and ester derivatives are inactive. Vice-versa many acid or amide derivatives show interesting antibacterial activity. The results obtained are discussed on the basis of structure-activity relationships.