Details

Autor(en) / Beteiligte

• Yu, Li
• Wang, Guo-Dong
• Ruan, Jue
• Chen, Yong-Bin
• Yang, Cui-Ping
• Cao, Xue
• Wu, Hong
• Liu, Yan-Hu
• Du, Zheng-Lin
• Wang, Xiao-Ping
• Yang, Jing
• Cheng, Shao-Chen
• Zhong, Li
• Wang, Lu
• Wang, Xuan
• Hu, Jing-Yang
• Fang, Lu
• Bai, Bing
• Wang, Kai-Le
• Yuan, Na
• Wu, Shi-Fang
• Li, Bao-Guo
• Zhang, Jin-Guo
• Yang, Ye-Qin
• Zhang, Cheng-Lin
• Long, Yong-Cheng
• Li, Hai-Shu
• Yang, Jing-Yuan
• Irwin, David M
• Ryder, Oliver A
• Li, Ying
• Wu, Chung-I
• Zhang, Ya-Ping

Titel

Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation

Ist Teil von

• Nature genetics, 2016-08, Vol.48 (8), p.947-952

Ort / Verlag

New York: Nature Publishing Group US

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Li Yu, Ya-Ping Zhang, Chung-I Wu and colleagues report the de novo genome of the black snub-nosed monkey Rhinopithecus bieti and the genomic sequences of four other Rhinopithecus species, including three high-altitude and two lowland species. The species- and population-level genomic analyses as well as the transcriptomic analysis and functional assays find adaptive signatures associated with adaptation to high altitude. The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. Rhinopithecus bieti , Rhinopithecus roxellana , and Rhinopithecus strykeri inhabit high-altitude habitats, whereas Rhinopithecus brelichi and Rhinopithecus avunculus inhabit lowland regions. We report the de novo whole-genome sequence of R. bieti and genomic sequences for the four other species. Eight shared substitutions were found in six genes related to lung function, DNA repair, and angiogenesis in the high-altitude snub-nosed monkeys. Functional assays showed that the high-altitude variant of CDT1 (Ala537Val) renders cells more resistant to UV irradiation, and the high-altitude variants of RNASE4 (Asn89Lys and Thr128Ile) confer enhanced ability to induce endothelial tube formation in vitro . Genomic scans in the R. bieti and R. roxellana populations identified signatures of selection between and within populations at genes involved in functions relevant to high-altitude adaptation. These results provide valuable insights into the adaptation to high altitude in the snub-nosed monkeys.