Details

Autor(en) / Beteiligte

• Ryotokuji, Takeshi
• Yamaguchi, Hiroki
• Ueki, Toshimitsu
• Usuki, Kensuke
• Kurosawa, Saiko
• Kobayashi, Yutaka
• Kawata, Eri
• Tajika, Kenji
• Gomi, Seiji
• Kanda, Junya
• Kobayashi, Anna
• Omori, Ikuko
• Marumo, Atsushi
• Fujiwara, Yusuke
• Yui, Shunsuke
• Terada, Kazuki
• Fukunaga, Keiko
• Hirakawa, Tsuneaki
• Arai, Kunihito
• Kitano, Tomoaki
• Kosaka, Fumiko
• Tamai, Hayato
• Nakayama, Kazutaka
• Wakita, Satoshi
• Fukuda, Takahiro
• Inokuchi, Koiti

Titel

Clinical characteristics and prognosis of acute myeloid leukemia associated with DNA-methylation regulatory gene mutations

Ist Teil von

• Haematologica (Roma), 2016-09, Vol.101 (9), p.1074-1081

Ort / Verlag

Italy

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• In recent years, it has been reported that the frequency of DNA-methylation regulatory gene mutations - mutations of the genes that regulate gene expression through DNA methylation - is high in acute myeloid leukemia. The objective of the present study was to elucidate the clinical characteristics and prognosis of acute myeloid leukemia with associated DNA-methylation regulatory gene mutation. We studied 308 patients with acute myeloid leukemia. DNA-methylation regulatory gene mutations were observed in 135 of the 308 cases (43.8%). Acute myeloid leukemia associated with a DNA-methylation regulatory gene mutation was more frequent in older patients (P<0.0001) and in patients with intermediate cytogenetic risk (P<0.0001) accompanied by a high white blood cell count (P=0.0032). DNA-methylation regulatory gene mutation was an unfavorable prognostic factor for overall survival in the whole cohort (P=0.0018), in patients aged ≤70 years, in patients with intermediate cytogenetic risk, and in FLT3-ITD-negative patients (P=0.0409). Among the patients with DNA-methylation regulatory gene mutations, 26.7% were found to have two or more such mutations and prognosis worsened with increasing number of mutations. In multivariate analysis DNA-methylation regulatory gene mutation was an independent unfavorable prognostic factor for overall survival (P=0.0424). However, patients with a DNA-methylation regulatory gene mutation who underwent allogeneic stem cell transplantation in first remission had a significantly better prognosis than those who did not undergo such transplantation (P=0.0254). Our study establishes that DNA-methylation regulatory gene mutation is an important unfavorable prognostic factor in acute myeloid leukemia.