Details

Autor(en) / Beteiligte

• Matson, C J
• Welter, A N
• Kvam, D C

Titel

An experimental non-invasive animal technique for measuring nasal airway resistance: I. Adrenergic and antihistaminic agents

Ist Teil von

• Archives internationales de pharmacodynamie et de thérapie, 1978-03, Vol.232 (1), p.68

Ort / Verlag

Belgium

Erscheinungsjahr

1978

Quelle

MEDLINE

Beschreibungen/Notizen

• A non-invasive technically simple and sensitive method is described for the determination of nasal airway resistance (NAR). Aerosolized saline elicited a +/- 7% change in baseline NAR, duration 2 minutes, whereas aerosolized histamine increased NAR, duration is greater than 30 minutes. Aerosolized phenylephrine, norepinephrine, and oxymetrazoline elicited dose related decongestive response in a naris subjected to prior congestion (aerosolized histamine). Both H1 and H2 receptors are involved in the congestive response to intranasal histamine.