Details

Autor(en) / Beteiligte

• Debacker, Clément S
• Daoust, Alexia
• Köhler, Sascha
• Voiron, Jérôme
• Warnking, Jan M
• Barbier, Emmanuel L

Titel

Impact of tissue T 1 on perfusion measurement with arterial spin labeling

Ist Teil von

• Magnetic resonance in medicine, 2017-04, Vol.77 (4), p.1656

Ort / Verlag

United States

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Arterial spin labeling (ASL) may provide quantitative maps of cerebral blood flow (CBF). Because labeled water exchanges with tissue water, this study evaluates the influence of tissue T on CBF quantification using ASL. To locally modify T , a low dose of manganese (Mn) was intracerebrally injected in one hemisphere of 19 rats (cortex or striatum). Tissue T and CBF were mapped using inversion recovery and continuous ASL experiments at 4.7T. Mn reduced the tissue T by more than 30% but had little impact on other tissue properties as assessed via dynamic susceptibility and diffusion MRI. Using a single-compartment model, the use of a single tissue T value yielded a mean relative ipsilateral (Mn-injected) to contralateral (noninjected) CBF difference of -34% in cortex and -22% in striatum tissue. With a T map, these values became -7% and +8%, respectively. A low dose of Mn reduces the tissue T without modifying CBF. Heterogeneous T impacts the ASL estimate of CBF in a region-dependent way. In animals, and when T modifications exceed the accuracy with which the tissue T can be determined, an estimate of tissue T should be obtained when quantifying CBF with an ASL technique. Magn Reson Med 77:1656-1664, 2017. © 2016 International Society for Magnetic Resonance in Medicine.