Nature structural & molecular biology, 2016-06, Vol.23 (6), p.522-530
2016
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- Autor(en) / Beteiligte
- Titel
- Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
- Ist Teil von
- Nature structural & molecular biology, 2016-06, Vol.23 (6), p.522-530
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Long noncoding RNAs (lncRNAs) play critical roles during tumorigenesis by functioning as scaffolds that regulate protein-protein, protein-DNA or protein-RNA interactions. Using a clinically guided genetic screening approach, we identified lncRNA in nonhomologous end joining (NHEJ) pathway 1 (LINP1), which is overexpressed in human triple-negative breast cancer. We found that LINP1 enhances repair of DNA double-strand breaks by serving as a scaffold linking Ku80 and DNA-PKcs, thereby coordinating the NHEJ pathway. Importantly, blocking LINP1, which is regulated by p53 and epidermal growth factor receptor (EGFR) signaling, increases the sensitivity of the tumor-cell response to radiotherapy in breast cancer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1545-9993eISSN: 1545-9985DOI: 10.1038/nsmb.3211Titel-ID: cdi_pubmed_primary_27111890
- Format
- –
- Schlagworte
- Breast - metabolism, Breast - pathology, Cell Line, Tumor, DNA Breaks, Double-Stranded, DNA End-Joining Repair, Epidermal Growth Factor - metabolism, Female, Gene Expression Regulation, Neoplastic, Humans, RNA, Long Noncoding - genetics, RNA, Long Noncoding - metabolism, Signal Transduction, Triple Negative Breast Neoplasms - genetics, Triple Negative Breast Neoplasms - metabolism, Triple Negative Breast Neoplasms - pathology, Tumor Suppressor Protein p53 - metabolism, Up-Regulation