Details

Autor(en) / Beteiligte

• Keeney, M
• Jiang, X. Y
• Yamane, M
• Lee, M
• Goodman, S
• Yang, F

Titel

Nanocoating for biomolecule delivery using layer-by-layer self-assembly

Ist Teil von

• Journal of materials chemistry. B, Materials for biology and medicine, 2015-01, Vol.3 (45), p.8757-877

Ort / Verlag

England

Erscheinungsjahr

2015

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Since its introduction in the early 1990s, layer-by-layer (LbL) self-assembly of films has been widely used in the fields of nanoelectronics, optics, sensors, surface coatings, and controlled drug delivery. The growth of this industry is propelled by the ease of film manufacture, low cost, mild assembly conditions, precise control of coating thickness, and versatility of coating materials. Despite the wealth of research on LbL for biomolecule delivery, clinical translation has been limited and slow. This review provides an overview of methods and mechanisms of loading biomolecules within LbL films and achieving controlled release. In particular, this review highlights recent advances in the development of LbL coatings for the delivery of different types of biomolecules including proteins, polypeptides, DNA, particles and viruses. To address the need for co-delivery of multiple types of biomolecules at different timing, we also review recent advances in incorporating compartmentalization into LbL assembly. Existing obstacles to clinical translation of LbL technologies and enabling technologies for future directions are also discussed. Schematic illustrates the formation of LbL coatings using different methods. (A) Electrostatic interactions; (B) Hydrogen bonding; or (C) Biological interactions.