Details

Autor(en) / Beteiligte

• Vuong, Celine K
• Black, Douglas L
• Zheng, Sika

Titel

The neurogenetics of alternative splicing

Ist Teil von

• Nature reviews. Neuroscience, 2016-05, Vol.17 (5), p.265

Ort / Verlag

England

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Alternative precursor-mRNA splicing is a key mechanism for regulating gene expression in mammals and is controlled by specialized RNA-binding proteins. The misregulation of splicing is implicated in multiple neurological disorders. We describe recent mouse genetic studies of alternative splicing that reveal its critical role in both neuronal development and the function of mature neurons. We discuss the challenges in understanding the extensive genetic programmes controlled by proteins that regulate splicing, both during development and in the adult brain.