Planta medica, 2016-05, Vol.82 (8), p.742
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Cytotoxic Diterpenoids from the Roots of Aralia melanocarpa
- Ist Teil von
- Planta medica, 2016-05, Vol.82 (8), p.742
- Ort / Verlag
- Germany
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Five new diterpenoids (1-5) were isolated from the roots of Aralia melanocarpa, together with four known compounds, 7β-hydroxy-ent-pimara-8(14),15-diene-19-oic acid (6), 18-norpimara-8(14),15-dien-4-ol (7), ent-16βH,17-isovalerate-kauran-19-oic acid (8), and ent-16α,17-dihydroxykauran-19-oic acid (9). Based on the MS, IR, and NMR spectral analysis, the structures of the five new diterpenoids (1-5) were elucidated. The cytotoxic activities of compounds 1-9 were assayed, and compounds 1 and 2 showed cytotoxicity in four cancer cell lines with IC50s from 4.2 to 8.2 µM.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1439-0221DOI: 10.1055/s-0042-104349Titel-ID: cdi_pubmed_primary_27093248
- Format
- –
- Schlagworte
- Antineoplastic Agents, Phytogenic - chemistry, Antineoplastic Agents, Phytogenic - isolation & purification, Aralia - chemistry, Cell Line, Diterpenes - chemistry, Diterpenes - isolation & purification, Diterpenes - pharmacology, Drug Screening Assays, Antitumor, Molecular Structure, Plant Roots - chemistry