Nature cell biology, 2016-04, Vol.18 (4), p.356-365
2016
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Details
- Autor(en) / Beteiligte
- Titel
- The ever-expanding role of HIF in tumour and stromal biology
- Ist Teil von
- Nature cell biology, 2016-04, Vol.18 (4), p.356-365
- Ort / Verlag
- England
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1465-7392eISSN: 1476-4679DOI: 10.1038/ncb3330Titel-ID: cdi_pubmed_primary_27027486
- Format
- –
- Schlagworte
- Basic Helix-Loop-Helix Transcription Factors - genetics, Basic Helix-Loop-Helix Transcription Factors - metabolism, Gene Expression Regulation, Neoplastic, Humans, Hypoxia, Hypoxia-Inducible Factor 1 - genetics, Hypoxia-Inducible Factor 1 - metabolism, Models, Biological, Neoplasms - blood supply, Neoplasms - genetics, Neoplasms - metabolism, Neovascularization, Pathologic - genetics, Neovascularization, Pathologic - metabolism, Signal Transduction - genetics, Tumor Microenvironment - genetics