Details

Autor(en) / Beteiligte

• Tasic, Bosiljka
• Menon, Vilas
• Nguyen, Thuc Nghi
• Kim, Tae Kyung
• Jarsky, Tim
• Yao, Zizhen
• Levi, Boaz
• Gray, Lucas T
• Sorensen, Staci A
• Dolbeare, Tim
• Bertagnolli, Darren
• Goldy, Jeff
• Shapovalova, Nadiya
• Parry, Sheana
• Lee, Changkyu
• Smith, Kimberly
• Bernard, Amy
• Madisen, Linda
• Sunkin, Susan M
• Hawrylycz, Michael
• Koch, Christof
• Zeng, Hongkui

Titel

Adult mouse cortical cell taxonomy revealed by single cell transcriptomics

Ist Teil von

• Nature neuroscience, 2016-02, Vol.19 (2), p.335

Ort / Verlag

United States

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Nervous systems are composed of various cell types, but the extent of cell type diversity is poorly understood. We constructed a cellular taxonomy of one cortical region, primary visual cortex, in adult mice on the basis of single-cell RNA sequencing. We identified 49 transcriptomic cell types, including 23 GABAergic, 19 glutamatergic and 7 non-neuronal types. We also analyzed cell type-specific mRNA processing and characterized genetic access to these transcriptomic types by many transgenic Cre lines. Finally, we found that some of our transcriptomic cell types displayed specific and differential electrophysiological and axon projection properties, thereby confirming that the single-cell transcriptomic signatures can be associated with specific cellular properties.