Details

Autor(en) / Beteiligte

• Anbazhagan, Rajeshkumar
• Su, Yu-An
• Tsai, Hsieh-Chih
• Jeng, Ru-Jong

Titel

MoS2–Gd Chelate Magnetic Nanomaterials with Core–Shell Structure Used as Contrast Agents in in Vivo Magnetic Resonance Imaging

Ist Teil von

• ACS applied materials & interfaces, 2016-01, Vol.8 (3), p.1827-1835

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Despite their frequent usages as contrast agents for in vivo MRI imaging, paramagnetic molecules continue to suffer from low resolution, physicochemical instability, and high toxicity. Herein, we present a molybdenum disulfide and gadolinium complex, as an alternative core–shell magnetic nanomaterial that exhibits enhanced paramagnetic property; 4.5-times longer water proton spin–lattice relaxation time (T 1) when compared to commercial gadolinium contrast agents; as well as lowered toxicity, extended blood circulation time, increased stability, and desirable excretion characteristic. Transmission electron microscopy (TEM) revealed smooth core–shell nanoparticles 100 nm in size with a shell width of approximately 10 nm. These findings suggest that the synthesized nanomaterial possesses high potential as a positive contrast agent for the enhancement of MRI imaging.