Details

Autor(en) / Beteiligte

• Behaegel, Jonathan
• Comet, Jean-Paul
• Bernot, Gilles
• Cornillon, Emilien
• Delaunay, Franck

Titel

A hybrid model of cell cycle in mammals

Ist Teil von

• Journal of bioinformatics and computational biology, 2016-02, Vol.14 (1), p.1640001

Ort / Verlag

Singapore

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Time plays an essential role in many biological systems, especially in cell cycle. Many models of biological systems rely on differential equations, but parameter identification is an obstacle to use differential frameworks. In this paper, we present a new hybrid modeling framework that extends René Thomas' discrete modeling. The core idea is to associate with each qualitative state "celerities" allowing us to compute the time spent in each state. This hybrid framework is illustrated by building a 5-variable model of the mammalian cell cycle. Its parameters are determined by applying formal methods on the underlying discrete model and by constraining parameters using timing observations on the cell cycle. This first hybrid model presents the most important known behaviors of the cell cycle, including quiescent phase and endoreplication.