Details

Autor(en) / Beteiligte

• Prescott, Thomas P.
• Papachristodoulou, Antonis

Titel

Designing Conservation Relations in Layered Synthetic Biomolecular Networks

Ist Teil von

• IEEE transactions on biomedical circuits and systems, 2015-08, Vol.9 (4), p.572-580

Ort / Verlag

United States: IEEE

Erscheinungsjahr

2015

Quelle

IEEE Electronic Library (IEL)

Beschreibungen/Notizen

• In Synthetic Biology, biomolecular networks are designed and constructed to perform specified tasks. Design strategies for these networks tend to center on tuning the parameters of mathematical models to achieve a specified behavior, and implementing these parameters experimentally. This design strategy often assumes a fixed network structure that defines the possible behaviors, which may be too restrictive for our purposes. This paper investigates the extent to which the state space of a synthetic network can also be designed and shaped by parametric tuning. We exploit timescale separation to implement new, nonlinear, tunable conservation relations that hold for all times beyond a fast transient. We demonstrate an application of this design strategy by flexibly constraining the possible behaviors of a gene regulatory network through the design of fast protein interactions.