Details

Autor(en) / Beteiligte

• Rohrbeck, R
• Rohrbeck, C M
• Putzke, H P
• Jonas, L
• Reding, R

Titel

The morphogenesis of the structural changes of the exocrine pancreas after ligation of the excretory duct

Ist Teil von

• Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR, 1989, Vol.22 (6), p.371

Ort / Verlag

Germany

Erscheinungsjahr

1989

Quelle

MEDLINE

Beschreibungen/Notizen

• The changes in the exocrine pancreas were investigated after ligature of the excretory duct in 51 Wistar rats. A qualitative microdetermination of the epithelial cells was carried out in the originated ductulus-like structures. The acinic epithelial cells grow atrophically first of all and become necrotic in the end. A dedifferentiated acinic cellular atrophy with metamorphosis to a ductulus-like cell type could not be observed. Proliferative and preproliferative events occur in the duct epithelial cells. Cystic ductulus-like structures originated from this. These fill out the former acinic areas by immature, few differentiated, pluripotent epithelial cells that look similar to embryonal pancreatic cells.