Details

Autor(en) / Beteiligte

• Nouga, Achille B
• Ndom, Jean C
• Mpondo, Emmanuel M
• Nyobe, Judith Caroline Ngo
• Njoya, Alain
• Meva'a, Luc M
• Cranwell, Phillipa B
• Howell, James A.S
• Harwood, Laurence M
• Wansi, Jean Duplex

Titel

New furoquinoline alkaloid and flavanone glycoside derivatives from the leaves of Oricia suaveolens and Oricia renieri (Rutaceae)

Ist Teil von

• Natural product research, 2016, Vol.30 (3), p.305-310

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2016

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Fractionation of the methanol extract of the leaves of Oricia renieri and Oricia suaveolens (Rutaceae) led to the isolation of 13 compounds including the hitherto unknown furoquinoline alkaloid named 6,7-methylenedioxy-5-hydroxy-8-methoxy-dictamnine (1) and a flavanone glycoside named 5-hydroxy-4′-methoxy-7- O -[α- l -rhamnopyranosyl(1‴→5″)-β- d -apiofuranosyl]-flavanoside (2) , together with 11 known compounds (3 – 13) . The structures of the compounds were determined by comprehensive analyses of their 1D and 2D NMR, mass spectral data and comparison. All compounds isolated were examined for their activity against human carcinoma cell lines. The alkaloids 1 , 5 , 12 , 13 and the phenolic 2 , 8 , 11 tested compounds exhibited non-selective moderate cytotoxic activity with IC ₅₀ 8.7–15.9 μM whereas compounds 3 , 4 , 6 , 7 , 9 and 10 showed low activity.