Biochemical Society transactions, 2015-06, Vol.43 (3), p.442-446
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Regulation of TRPML1 function
- Ist Teil von
- Biochemical Society transactions, 2015-06, Vol.43 (3), p.442-446
- Ort / Verlag
- England
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0300-5127eISSN: 1470-8752DOI: 10.1042/bst20140311Titel-ID: cdi_pubmed_primary_26009188
- Format
- –
- Schlagworte
- Alzheimer Disease - genetics, Alzheimer Disease - pathology, Endosomes - genetics, Gene Expression Regulation, HIV Infections - genetics, HIV Infections - pathology, Humans, Lysosomes - genetics, Mucolipidoses - genetics, Mucolipidoses - pathology, Mutation, Transient Receptor Potential Channels - biosynthesis, Transient Receptor Potential Channels - genetics