Details

Autor(en) / Beteiligte

• Alame-Emane, A K
• Xu, P
• Pierre-Audigier, C
• Cadet-Daniel, V
• Shen, X
• Sraouia, M
• Siawaya, J F Djoba
• Takiff, H
• Gao, Q
• Gicquel, B

Titel

Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance

Ist Teil von

• The international journal of tuberculosis and lung disease, 2015-06, Vol.19 (6), p.679-684

Ort / Verlag

France

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern. To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP). Isolates from two major urban centres--Paris (101 strains) and Shanghai (171 strains)--were investigated for the association of pncA mutations with resistance to drugs other than PZA. The proportion of pncA mutations found in INH-monoresistant strains was not increased. pncA mutations associated with PZA resistance were found almost exclusively in MDR-TB strains, underlining the importance of determining PZA resistance when treating MDR- or XDR-TB.