Nature genetics, 2015-06, Vol.47 (6), p.569-576
2015
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- Autor(en) / Beteiligte
- Titel
- Understanding multicellular function and disease with human tissue-specific networks
- Ist Teil von
- Nature genetics, 2015-06, Vol.47 (6), p.569-576
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Tissue and cell-type identity lie at the core of human physiology and disease. Understanding the genetic underpinnings of complex tissues and individual cell lineages is crucial for developing improved diagnostics and therapeutics. We present genome-wide functional interaction networks for 144 human tissues and cell types developed using a data-driven Bayesian methodology that integrates thousands of diverse experiments spanning tissue and disease states. Tissue-specific networks predict lineage-specific responses to perturbation, identify the changing functional roles of genes across tissues and illuminate relationships among diseases. We introduce NetWAS, which combines genes with nominally significant genome-wide association study (GWAS) P values and tissue-specific networks to identify disease-gene associations more accurately than GWAS alone. Our webserver, GIANT, provides an interface to human tissue networks through multi-gene queries, network visualization, analysis tools including NetWAS and downloadable networks. GIANT enables systematic exploration of the landscape of interacting genes that shape specialized cellular functions across more than a hundred human tissues and cell types.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1061-4036eISSN: 1546-1718DOI: 10.1038/ng.3259Titel-ID: cdi_pubmed_primary_25915600
- Format
- –
- Schlagworte
- Alzheimer Disease - genetics, Alzheimer Disease - metabolism, Bayes Theorem, Bayesian statistical decision theory, Cell interaction, Cells, Cultured, Datasets, Disease, Electronic health records, Experiments, Gene expression, Gene Expression Regulation, Gene Ontology, Gene Regulatory Networks, Genetic aspects, Genome-wide association studies, Genome-Wide Association Study, Genomes, Genomics, Humans, Hypertension - genetics, Hypertension - metabolism, Hypotheses, Innovations, Methods, Models, Biological, Myocytes, Smooth Muscle - physiology, Organ Specificity, Parkinson Disease - genetics, Parkinson Disease - metabolism, Protein Interaction Maps, Proteins, Tissues