Applied immunohistochemistry & molecular morphology, 2015-04, Vol.23 (4), p.308-312
2015
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- Autor(en) / Beteiligte
- Titel
- Primary mucinous adenocarcinoma of the epididymis: report of a rare case with molecular genetic characterization including mutation analysis of the TP53 gene
- Ist Teil von
- Applied immunohistochemistry & molecular morphology, 2015-04, Vol.23 (4), p.308-312
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We report a case of primary epididymal mucinous adenocarcinoma in a 60-year-old man who presented with a scrotal mass and subsequently developed pulmonary metastases. On immunohistochemistry the tumor was positive for villin and CK20 and negative for CK7, CDX2, and thyroid transcription factor-1. Molecular genetic analysis revealed an uncommon mutation; 249: AGG →ATG in the TP53 gene, which has not been previously described in association with a primary epididymal adenocarcinoma. Mutational analysis showed KRAS, BRAF, and VHL to be wild-type. No microsatellite instability was found.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1541-2016eISSN: 1533-4058DOI: 10.1097/PAI.0b013e3182389663Titel-ID: cdi_pubmed_primary_25839701
- Format
- –
- Schlagworte
- Adenocarcinoma, Mucinous - genetics, Adenocarcinoma, Mucinous - metabolism, Adenocarcinoma, Mucinous - pathology, Epididymis - metabolism, Epididymis - pathology, Genital Neoplasms, Male - genetics, Genital Neoplasms, Male - metabolism, Genital Neoplasms, Male - pathology, Humans, Lung Neoplasms - genetics, Lung Neoplasms - metabolism, Lung Neoplasms - pathology, Lung Neoplasms - secondary, Male, Middle Aged, Mutation, Neoplasm Metastasis, Tumor Suppressor Protein p53 - genetics, Tumor Suppressor Protein p53 - metabolism