Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2015, Vol.78 (1), p.16
2015
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Details
- Autor(en) / Beteiligte
- Titel
- GABA-ergic mechanism of cerebrovascular and antiischemic effects of docosahexaenoic acid
- Ist Teil von
- Ėksperimentalʹnaâ i kliničeskaâ farmacologiâ, 2015, Vol.78 (1), p.16
- Ort / Verlag
- Russia (Federation)
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- In experiments on rats, measurements of the local blood flow in the cortex of cerebrum with the aid of a laser Doppler flow meter showed that docosahexaenoic acid (DHA) enhanced the local cerebral circulation in animals with global transient cerebral ischemia, while not influencing that in intact animals. This vasodilatory effect of DHA in ischemized rats is blocked by bicuculline (specific GABA(A) receptor blocker), which is indicative of a GABA-ergic mechanisms of the vascular tone regulation. The results of radioligand binding assay in vitro showed the possibility of direct DHA interaction with cerebrovascular GABA(A) receptors.
- Sprache
- Russisch
- Identifikatoren
- ISSN: 0869-2092Titel-ID: cdi_pubmed_primary_25826869
- Format
- –
- Schlagworte
- Animals, Bicuculline - pharmacology, Blood Pressure - drug effects, Brain Ischemia - drug therapy, Brain Ischemia - metabolism, Brain Ischemia - pathology, Cerebral Cortex - blood supply, Cerebral Cortex - drug effects, Cerebral Cortex - metabolism, Cerebral Cortex - pathology, Docosahexaenoic Acids - pharmacology, GABA-A Receptor Antagonists - pharmacology, Injections, Intravenous, Laser-Doppler Flowmetry, Male, Pyridazines - metabolism, Radioligand Assay, Rats, Receptors, GABA-A - metabolism, Tritium, Vasodilation - drug effects, Vasodilator Agents - pharmacology