Details

Autor(en) / Beteiligte

• Fouotsa, Hugues
• Lannang, Alain Meli
• Dzoyem, Jean Paul
• Tatsimo, Simplice J N
• Neumann, Beate
• Mbazoa, Celine Djama
• Razakarivony, Andrianambinina Andriamarolahy
• Nkengfack, Augustin Ephrem
• Eloff, Jacobus N
• Sewald, Norbert

Titel

Antibacterial and antioxidant xanthones and benzophenone from garcinia smeathmannii

Ist Teil von

• Planta medica, 2015-05, Vol.81 (7), p.594-599

Ort / Verlag

Germany

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7-dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2D NMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent antibacterial activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 µg/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals.