Details

Autor(en) / Beteiligte

• Shiraishi, Akiko
• Hiraoka, Atsushi
• Aibiki, Toshihiko
• Okudaira, Tomonari
• Kawamura, Tomoe
• Imai, Yusuke
• Tatsukawa, Haruka
• Yamago, Hiroka
• Nakahara, Hiromasa
• Shimizu, Yuko
• Suga, Yoshihumi
• Azemoto, Nobuaki
• Tanihira, Tetsuya
• Miyata, Hideki
• Miyamoto, Yasunao
• Ninomiya, Tomoyuki
• Hirooka, Masashi
• Abe, Masanori
• Hiasa, Yoichi
• Matsuura, Bunzo
• Kawasaki, Hideki
• Furuya, Keizo
• Michitaka, Kojiro

Titel

Real-time tissue elastography: non-invasive evaluation of liver fibrosis in chronic liver disease due to HCV

Ist Teil von

• Hepato-gastroenterology, 2014-10, Vol.61 (135), p.2084

Ort / Verlag

Greece

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• We evaluated the diagnostic efficacy for advanced fibrosis of real-time tissue elastography (RTE), is a newly introduced non-invasive method, in hepatitis C virus (HCV) patients. Sixty-six chronic liver diseases with HCV (CLD-HCV) were evaluated by RTE, FIB-4, and APRI, as well as biopsy or hepatectomy findings. Seventeen healthy volunteers, and 1 with elevation of transaminase and 5 with liver tumors within their normal liver were enrolled for normal controls. Severe fibrosis was defined as METAVIR score 3 or 4. The tissue elasticity value was expressed by LF-index created by the program incorporated in the ultrasound device. The percentage of fibrosis area in each specimen (%FA) was determined with a personal computer. A receiver operating characteristic curve (ROC) was calculated for each non-invasive method of estimation of fibrosis. The values for the area under the ROC for LF-index, APRI, and FIB-4 were 0.88, 0.81, and 0.84, respectively. Accuracy, sensitivity, and specificity for prediction of LF-index (>2.8) for severe fibrosis were 86.5%, 78.6%, and 93.6%, respectively, which were better than those of FIB-4 and APRI. LF-index showed a good relationship to %FA (r=0.276, P=0.020). RTE is an effective method for predicting severe fibrosis in CLD-HCV.