Methods in molecular biology (Clifton, N.J.), 2015, Vol.1271, p.3
2015
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- Autor(en) / Beteiligte
- Titel
- The G protein-coupled receptor rhodopsin: a historical perspective
- Ist Teil von
- Methods in molecular biology (Clifton, N.J.), 2015, Vol.1271, p.3
- Ort / Verlag
- United States
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Rhodopsin is a key light-sensitive protein expressed exclusively in rod photoreceptor cells of the retina. Failure to express this transmembrane protein causes a lack of rod outer segment formation and progressive retinal degeneration, including the loss of cone photoreceptor cells. Molecular studies of rhodopsin have paved the way to understanding a large family of cell-surface membrane proteins called G protein-coupled receptors (GPCRs). Work started on rhodopsin over 100 years ago still continues today with substantial progress made every year. These activities underscore the importance of rhodopsin as a prototypical GPCR and receptor required for visual perception-the fundamental process of translating light energy into a biochemical cascade of events culminating in vision.
- Sprache
- Englisch
- Identifikatoren
- eISSN: 1940-6029DOI: 10.1007/978-1-4939-2330-4_1Titel-ID: cdi_pubmed_primary_25697513
- Format
- –
- Schlagworte
- Acylation - genetics, Acylation - physiology, Animals, Glycosylation, Humans, Light Signal Transduction - genetics, Light Signal Transduction - physiology, Lipoylation - genetics, Lipoylation - physiology, Membrane Proteins - chemistry, Membrane Proteins - metabolism, Phosphorylation - genetics, Phosphorylation - physiology, Protein Structure, Secondary, Receptors, G-Protein-Coupled - genetics, Receptors, G-Protein-Coupled - metabolism, Retinal Rod Photoreceptor Cells - cytology, Retinal Rod Photoreceptor Cells - metabolism, Rhodopsin - genetics, Rhodopsin - metabolism, Signal Transduction - genetics, Signal Transduction - physiology