Details

Autor(en) / Beteiligte

• Lewis, Huw D
• Liddle, John
• Coote, Jim E
• Atkinson, Stephen J
• Barker, Michael D
• Bax, Benjamin D
• Bicker, Kevin L
• Bingham, Ryan P
• Campbell, Matthew
• Chen, Yu Hua
• Chung, Chun-Wa
• Craggs, Peter D
• Davis, Rob P
• Eberhard, Dirk
• Joberty, Gerard
• Lind, Kenneth E
• Locke, Kelly
• Maller, Claire
• Martinod, Kimberly
• Patten, Chris
• Polyakova, Oxana
• Rise, Cecil E
• Rüdiger, Martin
• Sheppard, Robert J
• Slade, Daniel J
• Thomas, Pamela
• Thorpe, Jim
• Yao, Gang
• Drewes, Gerard
• Wagner, Denisa D
• Thompson, Paul R
• Prinjha, Rab K
• Wilson, David M

Titel

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Ist Teil von

• Nature chemical biology, 2015-03, Vol.11 (3), p.189-191

Ort / Verlag

United States

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and oncological diseases through clinical genetics and gene disruption in mice. New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular trap formation for, to our knowledge, the first time. The therapeutic potential of PAD4 inhibitors can now be explored.