Details

Autor(en) / Beteiligte

• Mahlknecht, Philipp
• Iranzo, Alex
• Högl, Birgit
• Frauscher, Birgit
• Müller, Christoph
• Santamaría, Joan
• Tolosa, Eduardo
• Serradell, Monica
• Mitterling, Thomas
• Gschliesser, Viola
• Goebel, Georg
• Brugger, Florian
• Scherfler, Christoph
• Poewe, Werner
• Seppi, Klaus

Titel

Olfactory dysfunction predicts early transition to a Lewy body disease in idiopathic RBD

Ist Teil von

• Neurology, 2015-02, Vol.84 (7), p.654-658

Ort / Verlag

United States

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of the present study was to determine the predictive value of olfactory dysfunction for the early development of a synuclein-mediated neurodegenerative disease in subjects with idiopathic REM sleep behavior disorder (iRBD) over an observational period of 5 years. Thirty-four patients with polysomnography-confirmed iRBD underwent olfactory testing using the entire Sniffin' Sticks test assessing odor identification, odor discrimination, and olfactory threshold. Patients with iRBD were prospectively followed up over a period of 4.9 ± 0.3 years (mean ± SD). The diagnosis of neurodegenerative diseases was based on current clinical diagnostic criteria. After 2.4 ± 1.7 years (mean ± SD), 9 patients (26.5%) with iRBD developed a Lewy body disease (6 Parkinson disease and 3 dementia with Lewy bodies). The entire Sniffin' Sticks test and the identification subtest had the same overall diagnostic accuracy of 82.4% (95% confidence interval: 66.1%-92.0%) in predicting conversion. The relative risk for a Lewy body disease in the lowest tertile of olfactory function was 7.3 (95% confidence interval: 1.8-29.6) compared with the top 2 tertiles. Assessment of olfactory function, particularly odor identification, may help to predict the development of a Lewy body disease in patients with iRBD over a relatively short time period and thus to identify patients suitable for future disease modification trials.