Details

Autor(en) / Beteiligte

• Rodríguez-Rubio, Lorena
• Gutiérrez, Diana
• Donovan, David M.
• Martínez, Beatriz
• Rodríguez, Ana
• García, Pilar

Titel

Phage lytic proteins: biotechnological applications beyond clinical antimicrobials

Ist Teil von

• Critical reviews in biotechnology, 2016-05, Vol.36 (3), p.542-552

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2016

Quelle

Taylor & Francis

Beschreibungen/Notizen

• Most bacteriophages encode two types of cell wall lytic proteins: endolysins (lysins) and virion-associated peptidoglycan hydrolases. Both enzymes have the ability to degrade the peptidoglycan of Gram-positive bacteria resulting in cell lysis when they are applied externally. Bacteriophage lytic proteins have a demonstrated potential in treating animal models of infectious diseases. There has also been an increase in the study of these lytic proteins for their application in areas such as food safety, pathogen detection/diagnosis, surfaces disinfection, vaccine development and nanotechnology. This review summarizes the more recent developments, outlines the full potential of these proteins to develop new biotechnological tools and discusses the feasibility of these proposals.