Zhong yao cai, 2014-07, Vol.37 (7), p.1222
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Experimental study and mechanism research of 701 diedazhentonggao on acute and chronic soft tissue injury in rabbit
- Ist Teil von
- Zhong yao cai, 2014-07, Vol.37 (7), p.1222
- Ort / Verlag
- China
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To study the effect and mechanism of 701 Diedazhentonggao on acute and chronic soft tissue injury in rabbit. The rabbit model of acute and chronic soft tissue injury were established by heavy hammer blow method. The tissue damage scored, pain threshold value and blood rheology were detected, and histopathological and inflammatory cytokines in damaged tissue and gene chip were observed. 701 Diedazhentonggao significantly improved the acute soft tissue injury symptoms, increased the pain threshold, reduced the score values of local damage, improved subcutaneous ecchymosis symptoms, reduced the content of inflammatory cytokines in damaged tissue, repaired the injuried tissue, and reduced blood viscosity and the content of IL-1 and 5-HT. But the contents of IL-6 and PGE2 in acute soft tissue injury were not reduced. The gene chip study expressed the drug interfered the pathway of IL-1R and white blood cell cling. 701 Diedazhentonggao also improved the chronic soft tissue injury symptoms and the main performance o
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1001-4454Titel-ID: cdi_pubmed_primary_25566661
- Format
- –
- Schlagworte
- Animals, Interleukin-1, Interleukin-6, Male, Rabbits, Signal Transduction, Soft Tissue Injuries - drug therapy