Details

Autor(en) / Beteiligte

• Zeng, Feng
• Wei, Shi-Jing
• Huang, Hao-Bo
• Huang, Qing-Hua
• Lin, Qiu-Yan
• Fan, Li-Ping
• Huang, Hui-Wen
• Fu, Dan-Hui

Titel

Analysis of the efficiency and influence factors of PBSC collection with AutoPBSC and MNC procedure of cell separator

Ist Teil von

• Zhongguo shi yan xue ye xue za zhi, 2014-12, Vol.22 (6), p.1684

Ort / Verlag

China

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• This study was aimed to analyze the efficiency and influence factors of PBSC collection by an automatic (AutoPBSC procedure) and a semiautomatic apheresis procedure ( MNC procedure) of COBE Spectra cell separators. According to the different objects, A total of 109 apheresis cases were divided into autologous cohort (patient) and allogeneic cohort (donor). The quantity and quality of the collections and the characteristics of apheresis procedure were compared, the yields and influence factors of two cohorts with two kinds of procedures were analyzed respectively. The results showed that the collections of two procedure in patients and donors which processed the similar blood volumes were insignificantly different in MNC%, CD34⁺ %, CD34⁺ cell counts and Hb concentration (P > 0.05) ; the collections by AutoPBSC procedure had got fewer platelets, less product volumes whereas more ACD-A used, longer apheresis time in comparison with MNC procedure (P < 0.05). Correlation analysis indicated that MNC (r = 0.314,P =