Details

Autor(en) / Beteiligte

• Kirova, Yu I
• Shakova, F M
• Germanova, E L
• Paltsyn, A A
• Romanova, G A
• Rybnikova, Ye A
• Lukyanova, L D

Titel

Urgent changes in the expression of hypoxia-inducible factor-1α (HIF-1α) in the neocortex of rats with different tolerance to acute hypoxia underwent focal ischemic stroke prefrontal cortex

Ist Teil von

• Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2014-07 (3), p.9

Ort / Verlag

Russia (Federation)

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Using immunohistochemical method, it was demonstrated that neurons of the cerebral cortex have the capacity to express hypoxia-inducible factor-1 alpha (HIF-1α) in normoxia. Intensity of this process is different for rats having unequal tolerance to hypoxia. Basal HIF-1α expression in neurons of rats with low-resistance (LR) to hypoxia is higher compared to rats with high-resistance (HR). Bilateral photochemically induced focal ischemic insult in the rat prefrontal cortex completely suppressed HIF-1α neuronal expression the in the ischemic zone and only partially--in the area of the penumbra. Neuronal injury was more pronounced in cortex of LR rats compared to HR rats. These findings suggest that functional significance of HIF-1α is greater in neurons of the cerebral cortex of LR rats compared to HR rats.